Meet Brunkow, Ramsdell and Sakaguchi - the Nobel Prize-winning trio who taught the world how the immune system knows when to stop
Published on: Oct. 6, 2025, 3:19 p.m. | Source: The Economic Times
Shimon Sakaguchi, Mary E. Brunkow, and Fred Ramsdell received the 2025 Nobel Prize in Medicine for decoding peripheral immune tolerance. Sakaguchi discovered regulatory T cells, while Brunkow and Ramsdell identified the Foxp3 gene controlling them. Their groundbreaking work transformed immunology, offering new avenues for treating autoimmune disorders, cancer, and transplant rejection.
